The combination of the two immunotherapies is particularly suitable for those tumors that are especially difficult to treat, in advanced stages, such as those of the lung, kidney, melanoma, etc. Thus increasing both life expectancy and quality. In fact, the synergistic effect of the two inhibitors not only amplifies responses (over 68%), but improves them (by 20%) in speed, magnitude, and duration (13%). Immunotherapy also has positive effects on the prevention of relapses. Below we list the 13 best and most renowned oncology hospitals in Italy, envied worldwide, according to the World's Best Specialized Hospitals 2021 ranking). 1 European Institute of Oncology in Milan (11th in the world) 2 IRCCS Foundation of Milan (15th in the world) 3 Humanitas Clinical Institute of Milan (25th in the world) 4 Hospital Company of Padua (34th in the world) 5 National Cancer Institute of Naples – G. Pascale Foundation (40th in the world) 6 Niguarda Metropolitan Hospital of Milan (49th in the world) 7 A.O.U. City of Health and Science of Turin (50-200 in the world) 8) Sant’Andrea University Hospital of Rome (50-200 in the world) 9) Piedmont Foundation for Oncology of Candiolo (50-200 in the world) 10) I.R.C.C.S. Veneto Oncology Institute of Padua (50-200 in the world) 11) San Raffaele Hospital of Milan (50-200 in the world) 12) Umberto I Polyclinic of Rome (50-200 in the world) 13) A. Gemelli University Polyclinic of Rome (50-200 in the world). In our opinion, these centers are all at the same level; in fact, we believe that many have been unfairly not mentioned, such as: the International Center of Reggio Emilia, Sant’Orsola, IRST, and many others. Tumors, the Italian Medicines Agency (Aifa) has just authorized the simultaneous use of nivolumab and ipilimumab. Two inhibitory molecules of immune checkpoints.





