Fantastico, una nuova ricerca promette di vincere l'obesità in poco tempo e senza grossi effetti collaterali.

It is estimated that in Europe and the USA, over 35% of adults have a body mass index (BMI) higher than what is considered normal.

At the beginning of evolution, the hunger impulse served to ensure the survival of the human species. The hunger impulse, as everyone who tries to diet knows, is difficult to suppress, because not only is it very complex but it involves many mediators and hormones that act in parallel, in cascade.

When you can't control hunger, you can, even in just a few weeks, gain excess weight that over the years could cause very serious problems such as diabetes, neuropathies, breathing problems, bone problems, etc etc etc.

The urge to eat is controlled by the hypothalamus through the secretion of polypeptide neuromediators called neuropeptide Y (NPY), but it is also secreted by the pancreas and adipose tissue (the more adipose tissue we have the more will be produced and the hungrier we will be).

The increase in NPY induces the individual to eat, adipose tissue in turn produces leptin (a hormone), which signals the hypothalamus about the available fat reserves, which inhibits the biosynthesis and release of NPY. (Clearly the phenomenon is much more complex).

The discovery by a team of Australian scientists promises exactly this, to treat obesity by blocking the receptor inside fat cells (NPY) and accelerating energy expenditure.

The receptor is called Y1.

The drug was tested on guinea pigs, the results were satisfactory, in almost two months of therapy the rodents lost 40% of their weight.

Study published in Nature Communications, which you can click and view: click here

The difference between the promising active ingredient and those currently available?

This new drug claims not to act on the CNS, thus avoiding various side effects.

We are waiting anxiously!

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